nucleosome-remodeling factor complex (NuRF complex)

Structure: - subunits include: SMARCA1, BPTF, RBBP4 & RBBP7

Properties

SUBUNITS: transcription activator SNF2L COMPARTMENT: cell nucleus MOTIF: helicase NAME: helicase SITE: 195-360 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 208-215 DEAD/H box NAME: DEAD/H box SITE: 311-314 Helicase C-terminal {490-653} Ser phosphorylation site {S725} SANT 1 {855-907} Tyr phosphorylation site {Y954} SANT 2 {958-1022} nucleosome-remodeling factor subunit BPTF COMPARTMENT: cytoplasm cell nucleus MOTIF: glutamate-rich region {143-180} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S216} DDT {240-300} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 390-437 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S572} coiled coil {574-604} KEAP1 interaction {640-749} Ser phosphorylation site {S763} Ser phosphorylation site {S817} MAZ interaction {839-921} MOTIF: Tyr phosphorylation site {Y839} Thr phosphorylation site {T909} coiled coil {978-1007} Thr phosphorylation site {T1064} Ser phosphorylation site {S1231} Ser phosphorylation site {S1300} threonine-rich region {1709-1803} MOTIF: threonine residue (SEVERAL) Ser phosphorylation site {S1827} Ser phosphorylation site {S1833} coiled coil {2022-2050} Ser phosphorylation site {S2098} threonine-rich region {2338-2361} MOTIF: threonine residue (SEVERAL) Ser phosphorylation site {S2465} coiled coil {2706-2732} proline-rich region SITE: 2795-2817 MOTIF: proline residue (SEVERAL) lysine-rich region {2848-2853} MOTIF: lysine residue (SEVERAL) Zn finger PHD-type NAME: Zn finger PHD-type SITE: 2867-2918 EFFECTOR-BOUND: Zn+2 MOTIF: binding site SITE: 2869-2869 FOR-BINDING-OF: Histone H3-K4Me3 binding site SITE: 2876-2876 FOR-BINDING-OF: Histone H3-K4Me3 binding site SITE: 2882-2882 FOR-BINDING-OF: Histone H3-K4Me3 binding site SITE: 2891-2891 FOR-BINDING-OF: Histone H3-K4Me3 bromodomain {2944-3014} histone-binding protein RBBP4 COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl WD repeat {122-155} WD repeat {175-206} WD repeat {225-256} WD repeat {271-302} WD repeat {315-346} WD repeat {372-403} histone-binding protein RBBP7 COMPARTMENT: cell nucleus MOTIF: WD repeat {121-152} WD repeat {174-205} WD repeat {224-255} WD repeat {270-301} WD repeat {314-345} Ser phosphorylation site {S354} WD repeat {371-402} Ser phosphorylation site {S413} Thr phosphorylation site {T416}

References

UniProt :accession Q09028

Components

global transcription activator SNF2L1; nucleosome-remodeling factor subunit SNF2L; ATP-dependent helicase SMARCA1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 (SMARCA1, SNF2L, SNF2L1) histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-remodeling factor subunit RBAP48 (RBBP4, RbAp48) histone-binding protein RBBP7; retinoblastoma-binding protein 7; RBBP-7; retinoblastoma-binding protein p46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46 (RBBP7, RBAP46, HAT2) nucleosome-remodeling factor subunit BPTF; bromodomain & PHD finger-containing transcription factor; fetal Alzheimer antigen; fetal Alz-50 clone 1 protein (BPTF, FAC1, FALZ)