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nucleoredoxin (NXN, NRX)
Function:
- redox-dependent negative regulator of the Wnt signaling pathway
- may function as a transcriptional regulator
- may regulate phosphatase 2A (putative)
- associates with the phosphatase 2A holoenzyme
- interacts with PPP2CA; the interaction is direct
- interacts with DVL1 (via PDZ domain); the interaction is direct & regulated by oxidative stress (putative)
Structure:
- belongs to the nucleoredoxin family
- contains 1 thioredoxin domain
Compartment: cytoplasm, cytosol (putative), nucleus
Alternative splicing: named isoforms=2
General
oxidoreductase
Properties
SIZE: entity length = 435 aa
MW = 48 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: thioredoxin domain
SITE: 167-321
MOTIF: cysteine residue {X1}
MODIFICATION: cysteine residue {X2}
cysteine residue {X2}
MODIFICATION: cysteine residue {X1}
Database Correlations
UniProt Q6DKJ4
Pfam PF00578
ENZYME 1.8.1.8
References
UniProt :accession Q6DKJ4