nucleoporin NUP53 (nuclear pore complex protein Nup53, nucleoporin Nup35, 35 kD nucleoporin, mitotic phosphoprotein 44, MP-44, NUP35, MP44, NUP53)

Function: 1) component of the nuclear pore complex 2) role in the association of MAD1 with nuclear pore complex 3) interacts with TMEM48/NDC1, lamin B, NUP93, NUP155, NUP205 Structure: 1) belongs to the Nup53 family 2) contains 1 MPPN domain (mitotic phosphoprotein N' end) Compartment: - nuclear pore complex - tightly associated with nuclear membrane & lamina

General

nucleoporin (nuclear pore complex protein) phosphoprotein

Properties

SIZE: MW = 35 kD entity length = 326 aa COMPARTMENT: nuclear membrane MOTIF: MPPN {167-252} Thr phosphorylation site {T273} Ser phosphorylation site {S279} Thr phosphorylation site {T280}

Database Correlations

OMIM 608140 UniProt Q8NFH5 Pfam PF05172

References

UniProt :accession Q8NFH5