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nucleoporin NDC1 (hNDC1, transmembrane protein 48, TMEM48, NDC1)
Function:
- component of the nuclear pore complex
- role in de novo assembly & insertion of nuclear pore complex in the nuclear envelope.
- required for nuclear pore complex & nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane & soluble nucleoporins, thus anchoring the nuclear pore complex in the membrane
- interacts with the NUP35/NUP53 (putative)
- phosphorylated
Structure: belongs to the NDC1 family
Compartment:
- nucleus, nuclear pore complex, membrane
- central core structure of the nuclear pore complex
Alternative splicing: named isoforms=4
General
nuclear protein
phosphoprotein
transmembrane 6 protein
Properties
SIZE: MW = 76 kD
entity length = 674 aa
COMPARTMENT: cell nucleus
MOTIF: cytoplasmic domain {1-24}
transmembrane domain {25-45}
Perinuclear space {46-68}
transmembrane domain {69-89}
cytoplasmic loop {90-114}
transmembrane domain {115-135}
Perinuclear space {136-165}
transmembrane domain {166-186}
cytoplasmic loop {187-225}
transmembrane domain {226-246}
Perinuclear space {247-272}
transmembrane domain {273-293}
cytoplasmic domain {294-674}
MOTIF: Ser phosphorylation site {S406}
Thr phosphorylation site {T414}
Ser phosphorylation site {S471}
Database Correlations
UniProt Q9BTX1
References
UniProt :accession Q9BTX1