Arf-GAP domain & FG repeat-containing protein 1; HIV-1 Rev-binding protein; nucleoporin-like protein RIP; Rev-interacting protein; Rev/Rex activation domain-binding protein (AGFG1, HRB, RAB, RIP)

Function: - required for vesicle docking or fusion during acrosome biogenesis (putative) - may play a role in RNA trafficking or localization - interacts with EPS15R & EPS15 - interacts with FCHO1 Structure: - O-glycosylated (putative) - contains FG repeats - the FG repeat region is required for HIV-1 Rev protein interaction - contains 1 Arf-GAP domain Compartment: - nucleus - cytoplasmic vesicle Alternative splicing: named isoforms=3 Expression: ubiquitously expressed Pathology: - interacts specifically with the HIV-1 Rev protein effector domain & promotes RNA export - promotes movement of Rev-responsive element-containing RNAs from the nuclear periphery to the cytoplasm (essential for HIV-1 replication)

Related

HIV-1 Rev-binding protein 2; Rev-interacting protein 1; Rip-1 (HRB2, KRR1) nucleoporin (nuclear pore complex protein) receptor-interacting serine/threonine protein kinase 1; serine/threonine protein kinase RIP; cell death protein RIP; receptor-interacting protein (RIPK1, RIP)

General

glycoprotein nuclear protein phosphoprotein zinc finger protein

Properties

SIZE: entity length = 562 aa MW = 58 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Arf-GAP domain NAME: Arf-GAP domain SITE: 11-135 MOTIF: Zn finger C4-type SITE: 29-52 EFFECTOR-BOUND: Zn+2 Thr phosphorylation site {T177} Ser phosphorylation site {S179} Ser phosphorylation site {S181} Ser glycosylation site {S367}

Database Correlations

OMIM 600862 UniProt P52594 Pfam PF01412 Entrez Gene 3267 Kegg hsa:3267

References

UniProt :accession P52594