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nucleoporin-like 2 (NLP-1, hCG1, NUP42 homolog, NUPL2, CG1)
Function:
1) export of mRNAs containing polyA tails from the nucleus into cytoplasm
2) component of the nuclear pore complex
3) interacts with nuclear export protein NXF1
4) interacts with GLE1L
- forms heterotrimer with NUP155 & GLE1L in vitro
Compartment:
- nucleus, nuclear pore complex, cytoplasmic side
- excluded from the nucleolus
Alternative splicing: named isoforms=3
Expression: ubiquitously expressed
Pathology:
1) may participate in the docking of HIV1 viral Vpr at the nuclear envelope
2) interacts with the HIV-1 virus proteins Rev & Vpr
General
nuclear protein
Properties
SIZE: MW = 45 kD
entity length = 423 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Zinc finger
NAME: Zinc finger
SITE: 1-24
EFFECTOR-BOUND: Zn+2
MOTIF: FG {14-15}
Vpr interaction {94-170}
MOTIF: FG {95-96}
FG {218-219}
FG {220-221}
serine-rich region {238-378}
MOTIF: serine residue (SEVERAL)
FG {265-266}
FG {271-272}
FG {288-289}
FG {290-291}
FG {311-312}
FG {336-337}
FG {345-346}
FG {364-365}
binding site
SITE: 365-423
FOR-BINDING-OF: nucleoporin GLE1
Database Correlations
UniProt O15504
Pfam PF00642
References
UniProt :accession O15504