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nucleoplasmin
One of at least 3 nuclear proteins than interact with histones
Function:
- binds to histone H2A & histone H2B
- dissociates from histone H2A & histone H2B upon formation of nucleosome
Structure: acidic protein
Specific
nucleoplasmin 1; nucleophosmin; NPM; nucleolar phosphoprotein B23; numatrin; nucleolar protein NO38 (NPM1, NPM)
nucleoplasmin 2 (NPM2)
nucleoplasmin 3 (NPM3)
General
adenosine triphosphatase (ATPase)
DNA-binding protein
Properties
SIZE: MW = 29 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
active site
MOTIF: adenine nucleotide-binding site
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 333
- Laskey RA et al
The role of nucleoplasmin in chromatin assembly and disassembly
Philos. Trans. R. Soc. Lond. B. Biol. Sci. 1993, 339268
PMID: 8098530
- Wikipedia: Nucleoplasmin ATPase
http://en.wikipedia.org/wiki/Nucleoplasmin_ATPase