nucleolar protein family A member 1; H/ACA ribonucleoprotein complex subunit 1; nucleolar protein family A member 1; snoRNP protein GAR1 (GAR1, NOLA1)

Function: - required for ribosome biogenesis & telomere maintenance - component of H/ACA small nucleolar ribonucleoprotein complex, which catalyzes pseudouridylation of rRNA - may also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme - associates with NOLC1/NOPP140 - H/ACA snoRNPs interact with the SMN complex - this is mediated by interaction between GAR1 & SMN1 or SMN2 - component of the telomerase holoenzyme complex Structure: - interaction with SMN1 requires at least one of the RGG-box regions - belongs to the GAR1 family Compartment: nucleus, nucleolus, Cajal body Alternative splicing: named isoforms=2

General

nuclear protein protein subunit

Properties

SIZE: entity length = 217 aa MW = 22 kD COMPARTMENT: cell nucleus MOTIF: RGG-box 1 {4-57} RGG-box 2 {169-217}

Database Correlations

OMIM 606468 UniProt Q9NY12 Pfam PF04410 Entrez Gene 54433 Kegg hsa:54433

References

UniProt :accession Q9NY12