nucleolar protein 8 (nucleolar protein Nop132, NOL8, C9orf34, NOP132)

Function: - role in regulation of gene expression at post-transcriptional level or in ribosome biogenesis - phosphorylated - interacts with the GTP form of RRAGA, RRAGC & RRAGD - interacts with NIP7 Structure: contains 1 RRM domain (RNA recognition motif) Compartment: nucleus, nucleolus Alternative splicing: named isoforms=4 Expression: - detected in skeletal muscle Pathology: - role in survival of diffuse-type gastric cancer cells - up-regulated in diffuse-type gastric cancers - role in regulation of gene expression at post-transcriptional level or in ribosome biogenesis in cancer cells

General

nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: MW = 132 kD entity length = 1167 aa COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 8-89 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S298} Thr phosphorylation site {T302} Ser phosphorylation site {S304} Ser phosphorylation site {S365} Ser phosphorylation site {S378} Thr phosphorylation site {T381} coiled coil {753-779} Ser phosphorylation site {S801} Ser phosphorylation site {S837} Ser phosphorylation site {S838} Ser phosphorylation site {S843} Ser phosphorylation site {S845} coiled coil {886-924} MOTIF: Thr phosphorylation site {T888} Ser phosphorylation site {S890} Ser phosphorylation site {S1082} Ser phosphorylation site {S1083} Ser phosphorylation site {S1084} Ser phosphorylation site {S1099}

Database Correlations

UniProt Q76FK4 Pfam PF00076

References

UniProt :accession Q76FK4