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nucleolar protein 3; apoptosis repressor with CARD; muscle-enriched cytoplasmic protein; Myp; nucleolar protein of 30 kD; Nop30 (NOL3, ARC, NOP)
Function:
- interacts with TFPT (putative)
- isoform 1
- may be involved in RNA splicing
- oligomerizes & binds to SFRS9/SRp30C
- interacts with NPM1
- isoform 2
- may inhibit apoptosis
- binds CASP2/caspase-2 & CASP8/caspase-8
- inhibits caspase-8 activity
Structure: contains 1 CARD domain
Compartment:
- isoform 1: nucleus, nucleolus
- isoform 2: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- highly expressed in heart & skeletal muscle
- expressed at low levels in placenta, liver, kidney & pancreas
General
nuclear protein
Properties
SIZE: entity length = 219 aa
MW = 24 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: CARD domain {4-95}
Database Correlations
OMIM 605235
UniProt O60936
Pfam PF00619
Entrez Gene 8996
Kegg hsa:8996
References
UniProt :accession O60936