nucleolar GTP-binding protein 2; autoantigen NGP-1 (GNL2, NGP1)

Function: - associates with pre-60S ribosomal subunits in the nucleolus, implicated in their matureation & nuclear export Structure: - belongs to the MMR1/HSR1 GTP-binding protein family NOG2 subfamily - contains 1 G (guanine nucleotide-binding) domain Compartment: nucleus, nucleolus Expression: - ubiquitously expressed at relatively low levels - highest expression in testes

General

guanine nucleotide regulatory protein (GNRP) nuclear protein phosphoprotein

Properties

SIZE: entity length = 731 aa MW = 84 kD COMPARTMENT: cell nucleus MOTIF: GTP-binding site SITE: 317-324 G {322-377} MOTIF: GTP-binding site SITE: 361-365 Ser phosphorylation site {S553} Ser phosphorylation site {S561} Ser phosphorylation site {S563} glutamate-rich region {565-571} MOTIF: glutamate residue (SEVERAL)

Database Correlations

OMIM 609365 UniProt Q13823 PFAM correlations Entrez Gene 29889 Kegg hsa:29889

References

UniProt :accession Q13823