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nucleolar & coiled-body phosphoprotein 1; 140 kD nucleolar phosphoprotein; Nopp140; hepatitis C virus NS5A-transactivated protein 13; HCV NS5A-transactivated protein 13; nucleolar 130 kD protein; nucleolar phosphoprotein p130 (NOLC1, KIAA0035, NS5ATP13)
Function:
- related to nucleologenesis
- may play a role in maintenance of the fundamental structure of the fibrillar center & dense fibrillar component in the nucleolus
- has intrinsic GTPase & ATPase activities
- may play an important role in transcription catalyzed by RNA polymerase 1
- undergoes rapid & massive phosphorylation/dephosphorylation cycles on CK2 & PKC sites
- CDK1 kinase may phosphorylate NOLC1 in M-phase
- interacts with RNA polymerase 1 194 kD subunit (RPA194) & with casein kinase-2
Structure: contains 1 LisH domain
Compartment:
- nucleus, nucleolus, cytoplasm
- shuttles between the nucleolus & the cytoplasm
- at telophase, it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase
Alternative splicing: named isoforms=3; alpha, beta
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 699 aa
MW = 74 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: LisH {10-42}
nuclear translocation signal {68-82}
Ser phosphorylation site {S83}
repeat {84-566}
MOTIF: consensus repeat {84-95}
Ser phosphorylation site {S84}
Ser phosphorylation site {S85}
Ser phosphorylation site {S87}
Ser phosphorylation site {S90}
Ser phosphorylation site {S91}
consensus repeat {125-136}
consensus repeat {167-178}
Thr phosphorylation site {T188}
RPA194 interaction {204-382}
consensus repeat {221-232}
consensus repeat {264-275}
consensus repeat {325-336}
consensus repeat {363-375}
Ser phosphorylation site {S366}
nuclear translocation signal {384-587}
MOTIF: Ser phosphorylation site {S397}
consensus repeat {425-436}
consensus repeat {470-481}
Ser phosphorylation site {S508}
consensus repeat {519-529}
Ser phosphorylation site {S538}
consensus repeat {555-566}
Ser phosphorylation site {S563}
Ser phosphorylation site {S580}
Ser phosphorylation site {S582}
nuclear translocation signal {601-617}
MOTIF: Thr phosphorylation site {T607}
Thr phosphorylation site {T610}
Ser phosphorylation site {S622}
Ser phosphorylation site {S623}
Ser phosphorylation site {S643}
Ser phosphorylation site {S686}
Ser phosphorylation site {S698}
Database Correlations
OMIM 602394
UniProt Q14978
Pfam PF05022
Entrez Gene 9221
Kegg hsa:9221
References
UniProt :accession Q14978