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nuclear respiratory factor 1; NRF-1; alpha palindromic-binding protein; alpha-pal (NRF1)
Function:
- transcription factor
- activates expression of the EIF2S1 (EIF2-alpha) gene
- links transcriptional modulation of key metabolic genes to cellular growth & development
- implicated in control of nuclear genes required for respiration, heme biosynthesis, & mitochondrial DNA transcription & replication
- phosphorylation enhances DNA binding
- homodimer
- binds DNA as a dimer
- interacts with PPRC1
Structure: belongs to the NRF1/Ewg family
Compartment: nucleus
Alternative splicing: named isoforms=2; long, short
Expression:
- ubiquitously expressed
- strongest expression in skeletal muscle
General
DNA-binding protein
phosphoprotein
transcription factor (TF)
Properties
SIZE: entity length = 503 aa
MW = 54 kD
COMPARTMENT: cell nucleus
MOTIF: Dimerization {1-78}
MOTIF: Ser phosphorylation site {S39}
acidic region {41-66}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S44}
Ser phosphorylation site {S46}
Ser phosphorylation site {S47}
Ser phosphorylation site {S52}
alanine-rich region {80-86}
MOTIF: alanine residue (SEVERAL)
nuclear translocation signal {88-116}
DNA-binding motif
SITE: 109-305
transcriptional activation domain
SITE: 301-476
Database Correlations
OMIM 600879
UniProt Q16656
PFAM correlations
Entrez Gene 4899
Kegg hsa:4899
References
- UniProt :accession Q16656
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/NRF1ID44233ch7q32.html