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nuclear hormone receptor family
Function:
- ligand-activated transcription factors that regulate eukaryotic gene expression & affect cellular proliferation & differentiation in target tissues
- transcription factor activity is modulated by bound coactivator & corepressor proteins
- cytoplasmic anchoring facilitated by heat shock proteins
- steroid receptors are nuclear hormone receptors
* see figure A & figure B ligands for nuclear hormone receptors
Specific
bile acid receptor; nuclear receptor subfamily 1 group H member 4; farnesoid X-activated receptor; farnesol receptor HRR-1; retinoid X receptor-interacting protein 14; RXR-interacting protein 14 (NR1H4, BAR, FXR, HRR1, RIP14)
ecdysone receptor
nuclear hormone receptor NOR-1 (orphan nuclear receptor NR4A3, neuron-derived orphan receptor 1, mitogen-induced nuclear orphan receptor,nuclear receptor subfamily 4 group A member 3, NR4A3, CHN, CSMF, NOR1, TEC)
nuclear hormone receptor NR1 subfamily
nuclear hormone receptor NR2 subfamily
nuclear hormone receptor NR3 subfamily
nuclear hormone receptor NR4 subfamily
nuclear hormone receptor NR5 subfamily
nuclear receptor 0B2 (nuclear receptor subfamily 0 group B member 2, orphan nuclear receptor SHP, small heterodimer partner, NR0B2, SHP)
orphan nuclear receptor NR1D2; nuclear receptor subfamily 1 group D member 2; Rev-erb-beta; EAR-1R; rev-erbA-alpha-related receptor; orphan nuclear hormone receptor BD73; rev-erb (NR1D2, RVR)
orphan nuclear receptor NR2E1 (nuclear receptor subfamily 2 group E member 1, nuclear receptor TLX, tailless homolog, Tll, hTll, NR2E1, TLX)
orphan nuclear receptor NR6A1 (nuclear receptor subfamily 6 group A member 1, germ cell nuclear factor, GCNF, retinoid receptor-related testis-specific receptor, RTR, NR6A1, GCNF)
photoreceptor-specific nuclear receptor (retina-specific nuclear receptor, nuclear receptor subfamily 2 group E member 3, NR2E3, PNR, RNR)
steroid receptor
General
DNA-binding protein
receptor
transcription factor (TF)
Figures/Diagrams
Figures/diagrams/slides/tables related to nuclear hormone receptor
Properties
COMPARTMENT: cytoplasm
MOTIF: allosteric site
DNA-binding motif
MOTIF: kxffkr
NAME: kxffkr
FOR-BINDING-OF: calreticulin
FORM: kxffkr
Zinc finger
NAME: Zinc finger (2)
EFFECTOR-BOUND: Zn+2
ligand-binding site
References
- Alberts et al Molecular Biology of the Cell, 2nd ed.
1989, pg 704
- Binart N, Chambraud B, Levin JM, Garnier J, Baulieu EE.
A highly charged sequence of chick hsp90: a good candidate
for interaction with steroid receptors.
J Steroid Biochem. 1989;34(1-6):369-74.
PMID: 2626030
- Amero SA, Kretsinger RH, Moncrief ND, Yamamoto KR, Pearson WR.
The origin of nuclear receptor proteins: a single precursor
distinct from other transcription factors.
Mol Endocrinol. 1992 Jan;6(1):3-7. Review. No abstract available.
PMID: 1738368