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nuclear receptor subfamily 1 group D member 1; Rev-erbA-alpha; V-erbA-related protein 1; EAR-1 (NR1D1, EAR1, HREV, THRAL)

Function: - constitutive transcriptional repressor - possible receptor for triiodothyronine - interacts with C1D (putative) Structure: - composed of 3 domains: a) modulating N-terminal domain b) DNA-binding domain c) C-terminal steroid-binding domain - belongs to the nuclear hormone receptor family, NR1 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus (putative) Expression: - expressed in all tissues & cell lines examined Pathology: - expressed at high levels in some squamous carcinoma cell lines

Related

orphan nuclear receptor NR1D2; nuclear receptor subfamily 1 group D member 2; Rev-erb-beta; EAR-1R; rev-erbA-alpha-related receptor; orphan nuclear hormone receptor BD73; rev-erb (NR1D2, RVR)

General

nuclear hormone receptor NR1 subfamily phosphoprotein receptor zinc finger protein

Properties

SIZE: entity length = 614 aa MW = 67 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S23} serine-rich region {82-93} MOTIF: serine residue (SEVERAL) DNA-binding motif SITE: 129-205 MOTIF: Zn finger C4-type SITE: 132-152 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 169-193 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 602408 UniProt P20393 PFAM correlations Entrez Gene 9572 Kegg hsa:9572

References

  1. UniProt :accession P20393
  2. OMIM :accession 602408