nuclear receptor interaction protein; NRIP; IQ motif & WD repeat-containing protein 1; androgen receptor complex-associated protein (ARCAP, IQWD1, DCAF6)

Function: - ligand-dependent coactivator of nuclear receptors - enhances transcriptional activity of the nuclear receptors NR3C1 & AR - interacts with the nuclear receptors NR3C1 & AR in the presence of ligand Structure: - contains 1 IQ domain - contains 7 WD repeats Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - highly expressed in skeletal muscle & testis - expressed to a lesser degree in heart, prostate, & adrenal gland

General

nuclear protein WD repeat protein family

Properties

SIZE: entity length = 860 aa MW = 96 kD COMPARTMENT: cell nucleus MOTIF: WD repeat {49-88} WD repeat {92-133} WD repeat {139-179} WD repeat {189-229} WD repeat {251-290} IQ motif {676-705} WD repeat {718-756} WD repeat {759-798}

Database Correlations

UniProt Q58WW2 PFAM correlations

References

UniProt :accession Q58WW2