Search
nuclear receptor-binding factor 2; NRBF-2; comodulator of PPAR & RXR (NRBF2, COPR)
Function:
1) modulation of transcriptional activation by nuclear receptors (putative)
2) transcriptional activator (in vitro)
3) interacts with PPARA, PPARD & PPARG
4) interacts with RARA, RARG & RXRA in the presence of bound ligand
5) interacts with SCOC
Compartment: nucleus, cytoplasm
Alternative splicing: named isoforms=2
Expression:
- expressed in keratinocytes, liver, placenta
General
phosphoprotein
transcriptional adaptor protein; transcriptional coactivator
Properties
SIZE: entity length = 287 aa
MW = 32 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Thr phosphorylation site {T90}
Ser phosphorylation site {S105}
Ser phosphorylation site {S113}
Ser phosphorylation site {S120}
Nuclear receptor interaction {141-145}
coiled coil {168-209}
Ser phosphorylation site {S268}
Ser phosphorylation site {S277}
Database Correlations
UniProt Q96F24
Pfam PF08961
Entrez Gene 29982
Kegg hsa:29982
References
UniProt :accession Q96F24