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nuclear receptor 0B2 (nuclear receptor subfamily 0 group B member 2, orphan nuclear receptor SHP, small heterodimer partner, NR0B2, SHP)
Function:
1) acts as a negative regulator of receptor-dependent signaling
2) inhibits transactivation of nuclear receptor with which it interacts
3) interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG, HNF4A
Structure:
- belongs to the nuclear hormone receptor family, NR0 subfamily
Compartment: nucleus
Expression: expressed in liver > heart, pancreas
Pathology:
- defects in NR0B2 associated with early-onset obesity
Related
familial obesity
General
nuclear hormone receptor family
Properties
SIZE: MW = 28 kD
entity length = 257 aa
COMPARTMENT: cytoplasm
MOTIF: allosteric site
DNA-binding motif
MOTIF: kxffkr
NAME: kxffkr
FOR-BINDING-OF: calreticulin
FORM: kxffkr
Zinc finger
NAME: Zinc finger (2)
EFFECTOR-BOUND: Zn+2
ligand-binding site
binding site
SITE: 57-228
FOR-BINDING-OF: ligand
Database Correlations
OMIM correlations
MORBIDMAP 604630
UniProt Q15466
Pfam PF00104
Kegg hsa:8431
References
UniProt :accession Q15466