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nuclear protein NP94; Cip1-interacting zinc finger protein; CDKN1A-interacting zinc finger protein 1; zinc finger protein 356 (CIZ1, LSFR1, NP94, ZNF356)
Function:
- may regulate the subcellular localization of CIP/WAF1
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with CIP/WAF1
Structure: contains 1 matrin-type Zn+2 finger
Compartment: nucleus
Alternative splicing: named isoforms=4
General
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 898 aa
MW = 100 kD
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {4-44}
MOTIF: glutamine residue (SEVERAL)
Thr phosphorylation site {T244}
glutamine-rich region {276-470}
MOTIF: glutamine residue (SEVERAL)
Thr phosphorylation site {T567}
glutamate-rich region {741-761}
MOTIF: glutamate residue (SEVERAL)
Zn finger matrin-type
NAME: Zn finger matrin-type
SITE: 799-830
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S868}
Database Correlations
OMIM 611420
UniProt Q9ULV3
Pfam PF12171
Entrez Gene 25792
Kegg hsa:25792
References
- UniProt :accession Q9ULV3
- NIEHS-SNPs
http://egp.gs.washington.edu/data/ciz1/