nuclear protein NP60; nuclear protein of 60 kD; 3-hydroxyisobutyrate dehydrogenase-like protein; cytokine-like nuclear factor N-PAC (NP60, GLYR1, HIBDL)

Function: - regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 & specifically regulating MAPK14 signaling - indirectly promotes phosphorylation of MAPK14 & activation of ATF2 - phosphorylation of MAPK14 requires upstream activity of MAP2K4 & MAP2K6 - interacts with MAPK14 Structure: - A.T hook DNA-binding domain is required for interaction with MAPK14 - belongs to the 3-hydroxyisobutyrate dehydrogenase family, NP60 subfamily - contains 1 A.T hook DNA-binding domain - contains 1 PWWP domain Compartment: nucleus Alternative splicing: named isoforms=4

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 553 aa MW = 61 kD COMPARTMENT: cell nucleus MOTIF: PWWP domain {8-66} Ser phosphorylation site {S130} Ser phosphorylation site {S132} Ser phosphorylation site {S167} A+T hook SITE: 168-180

Database Correlations

UniProt Q49A26 PFAM correlations

References

UniProt :accession Q49A26