nuclear mitotic apparatus protein 1; NuMA protein; SP-H antigen (NUMA1 NUMA)

Function: 1) cell cycle related protein 2) essential for mitotic spindle formation 3) may be a structural component of the nucleus 4) C-terminal fragment interacts with importin beta Compartment: 1) nucleus 2) dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina 3) reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident Alternative splicing: named isoforms=2 Pathology: - chromosomal translocation with retinoic acid gene - DNA binding domains of RARA fused to 5' exons of NuMA in rare cases of acute promyelocytic leukemia

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 2115 aa MW = 238 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S169} Ser phosphorylation site {S172} Ser phosphorylation site {S198} Ser phosphorylation site {S200} Ser phosphorylation site {S203} Thr phosphorylation site {T211} coiled coil {213-1699} MOTIF: Ser phosphorylation site {S271} Ser phosphorylation site {S388} Ser phosphorylation site {S395} Ser phosphorylation site {S820} Thr phosphorylation site {T963} Ser phosphorylation site {S1225} Ser phosphorylation site {S1262} Ser phosphorylation site {S1280} Ser phosphorylation site {S1601} Ser phosphorylation site {S1721} Ser phosphorylation site {S1724} Ser phosphorylation site {S1728} Thr phosphorylation site {T1733} Ser phosphorylation site {S1757} Ser phosphorylation site {S1760} Ser phosphorylation site {S1769} Ser phosphorylation site {S1772} Tyr phosphorylation site {Y1774} Thr phosphorylation site {T1776} Ser phosphorylation site {S1788} Ser phosphorylation site {S1789} Ser phosphorylation site {S1792} Ser phosphorylation site {S1800} Thr phosphorylation site {T1804} Ser phosphorylation site {S1830} Ser phosphorylation site {S1833} Ser phosphorylation site {S1834} Tyr phosphorylation site {Y1836} Ser phosphorylation site {S1837} Ser phosphorylation site {S1840} Ser phosphorylation site {S1847} Ser phosphorylation site {S1853} Ser phosphorylation site {S1862} Ser phosphorylation site {S1872} Ser phosphorylation site {S1887} Ser phosphorylation site {S1945} Ser phosphorylation site {S1969} Ser phosphorylation site {S1991} Thr phosphorylation site {T2000} Thr phosphorylation site {T2055} Ser phosphorylation site {S2074} Ser phosphorylation site {S2077} Thr phosphorylation site {T2106}

Database Correlations

OMIM 164009 UniProt Q14980 Entrez Gene 4926 Kegg hsa:4926