nuclear migration protein nudC (nuclear distribution protein C homolog, NUDC)

Function: 1) role in neurogenesis & neuronal migration 2) necessary for correct formation of mitotic spindles & chromosome separation during mitosis 3) necessary for cytokinesis & cell proliferation 4) binds PLK1, PAFAH1B1 5) component of a complex containing PLK1, NUDC, dynein & dynactin 6) phosphorylated on Ser during M phase of cell cycle phosphorylation on Ser-274 & Ser-326 is necessary for correct formation of mitotic spindles & chromosome separation during mitosis phosphorylated by PLK & other kinases Structure: contains 1 CS domain Compartment: - cytoplasm, nucleus - in a filamentous pattern adjacent to nucleus of migrating cerebellar granule cells - colocalizes with tubulin & dynein & with microtubule organizing center - distributed throughout cytoplasm of non-migrating cells - small proportion is nuclear, in a punctate pattern Expression: - ubiquitous - expressed in fetal liver, kidney, lung, brain - expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain, heart - up-regulated in actively dividing hematopoietic precursor cells - up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor - down-regulated during maturation of erythroid precursor cells

Properties

SIZE: MW = 38 kD entity length = 331 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: coiled coil {60-134} MOTIF: nuclear translocation signal {68-74} CS {167-258} Ser phosphorylation site {S274} Ser phosphorylation site {S326}

Database Correlations

UniProt Q9Y266 Pfam PF04969

References

UniProt :accession Q9Y266