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CTD small phosphatase-like protein; CTDSP-like; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; NIF-like protein; nuclear LIM interactor-interacting factor 1; NLI-interacting factor 1; protein YA22; hYA22; RBSP3; small C-terminal domain phosphatase 3; SCP3; small CTD phosphatase 3 (CTDSPL, C3orf8, NIF1, NIFL, SCP3, YA22)
Function:
- preferentially catalyzes dephosphorylation of Ser-5 within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase 2 subunit POLR2A
- negatively regulates RNA polymerase 2 transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (putative)
- recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells
- interacts with REST
Cofactor: binds 1 Mg+2 per monomer (putative)
Structure:
- monomer
- contains 1 FCP1 homology domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Expression:
- expression is restricted to non-neuronal tissues
Related
LIM domain
LIM domain protein kinase
General
nuclear LIM interactor-interacting factor (NLI-interacting factor)
phosphoprotein
Properties
SIZE: entity length = 276 aa
MW = 31 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S28}
FCP1 homology {102-260}
MOTIF: aspartate residue {D112}
Mg+2-binding site
SITE: 112-112
aspartate residue {D114}
Mg+2-binding site
SITE: 114-114
threonine residue {168}
lysine residue {206}
Mg+2-binding site
SITE: 223-223
STATE: active state
Database Correlations
OMIM 608592
UniProt O15194
Pfam PF03031
Entrez Gene 10217
Kegg hsa:10217
ENZYME 3.1.3.16
References
UniProt :accession O15194