nuclear LIM interactor-interacting factor (NLI-interacting factor)

Function: - preferentially catalyzes dephosphorylation of Ser-5 within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase 2 subunit POLR2A - negatively regulates RNA polymerase 2 transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (putative) - recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells - interacts with REST Cofactor: binds 1 Mg⁺² per monomer (putative) Structure: - monomer - contains 1 FCP1 homology domain Compartment: nucleus (putative) Expression: - expression is restricted to non-neuronal tissues

Related

LIM domain LIM domain protein kinase

Specific

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; nuclear LIM interactor-interacting factor 3; NLI-IF; NLI-interacting factor 3; small C-terminal domain phosphatase 1; SCP1; small CTD phosphatase 1 (CTDSP1, NIF3, NLIIF, SCP1) carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; nuclear LIM interactor-interacting factor 2; NLI-interacting factor 2; protein OS-4; small C-terminal domain phosphatase 2; small CTD phosphatase 2; SCP2 (CTDSP2, NIF2, OS4, SCP2) CTD small phosphatase-like protein; CTDSP-like; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; NIF-like protein; nuclear LIM interactor-interacting factor 1; NLI-interacting factor 1; protein YA22; hYA22; RBSP3; small C-terminal domain phosphatase 3; SCP3; small CTD phosphatase 3 (CTDSPL, C3orf8, NIF1, NIFL, SCP3, YA22)

General

nuclear protein phosphoprotein phosphatase

Properties

COMPARTMENT: cell nucleus STATE: active state MOTIF: active site

References

UniProt :accession O14595