Contents

Search

nuclear hormone receptor NOR-1 (orphan nuclear receptor NR4A3, neuron-derived orphan receptor 1, mitogen-induced nuclear orphan receptor,nuclear receptor subfamily 4 group A member 3, NR4A3, CHN, CSMF, NOR1, TEC)

Function: binds to the B1A response-element Structure: - belongs to the nuclear hormone receptor family, NR4 subfamily - contains 1 nuclear receptor DNA-binding domain Compartment: nucleus (putative) Alternative splicing: named isoforms=2: alpha, beta Expression: - high expression of isoform alpha in skeletal muscle - high expression of isoform beta in skeletal muscle - low expression in fetal brain & placenta Pathology: - chromosomal translocations involving NR4A3 are a cause of a) Ewing sarcoma t(9;22)(q22-31;q11-12) NR4A3 with EWS b) a form of extraskeletal myxoid chondrosarcoma t(9;22)(q22-31;q11-12) NR4A3 with TAF2N

Related

EWS gene

General

nuclear hormone receptor family orphan receptor

Properties

SIZE: MW = 68 kD entity length = 626 aa COMPARTMENT: cell nucleus MOTIF: histidine-rich region {95-108} MOTIF: histidine residue (SEVERAL) serine-rich region {282-287} MOTIF: serine residue (SEVERAL) DNA-binding motif SITE: 289-364 MOTIF: Zn finger C4-type SITE: 292-312 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 328-352 EFFECTOR-BOUND: Zn+2 binding site SITE: 440-490 FOR-BINDING-OF: ligand

Database Correlations

OMIM correlations UniProt Q92570 PFAM correlations Kegg hsa:8013

References

  1. Uniprot Q92570
  2. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/TECID75.html