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nuclear factor Y; CAAT-box DNA-binding protein; CCAAT-binding transcription factor; CBF, (NFY)
Function:
1) stimulates transcription of various genes by recognizing & binding to a CCAAT motif in promoters, including type 1 collagen, albumin & beta-actin genes
2) NFYB & NFYC must interact & dimerize for NFYA association & DNA binding
Structure:
- subunits: NFYA, NFYB & NFYC
General
multisubunit protein
nuclear protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: NF-Y protein chain A
MOTIF: glutamine-rich region {14-161}
MOTIF: glutamine residue (SEVERAL)
Subunit association domain (SAD) {266-282}
DNA-binding motif
SITE: 298-318
NF-Y protein chain B
MOTIF: A {1-52}
B {53-142}
MOTIF: DNA-binding motif
SITE: 59-65
SAD {86-97}
C {143-207}
NF-Y protein chain C
References
- UniProt :accession P25208, P23511
- OMIM :accession 189903, 189904
Components
NF-Y protein chain A {alpha} (CAAT-box DNA-binding protein subunit A, CCAAT-binding transcription factor subunit B, CBF-B, NFYA)
NF-Y protein chain B {beta}; CAAT-box DNA-binding protein subunit B; CCAAT-binding transcription factor subunit A; CBF-A, (NFYB)
NF-Y protein chain C {gamma}; CAAT-box DNA-binding protein subunit C; CCAAT-binding transcription factor subunit C; transactivator HSM-1/2 (NFYC)