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nuclear factor 1 C-type; NF1-C; nuclear factor 1/C; CCAAT-box-binding transcription factor; CTF; nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein (NFIC, NFI)
Function:
- recognizes & binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral & cellular promoters & in the origin of replication of adenovirus type 2
- these proteins are individually capable of activating transcription & replication
- binds DNA as a homodimer
Structure:
- belongs to the CTF/NF-I family
- contains 1 CTF/NF-I DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=5
General
nuclear factor 1; CCAAT box-binding transcription factor; CTF; TGGCA-binding protein
phosphoprotein
Properties
SIZE: entity length = 508 aa
MW = 56 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 1-195
MOTIF: Ser phosphorylation site {S4}
Ser phosphorylation site {S194}
Ser phosphorylation site {S294}
Ser phosphorylation site {S304}
Ser phosphorylation site {S305}
Ser phosphorylation site {S323}
Ser phosphorylation site {S333}
Ser phosphorylation site {S337}
Ser phosphorylation site {S339}
Ser phosphorylation site {S343}
Thr phosphorylation site {T378}
Database Correlations
OMIM 600729
UniProt P08651
PFAM correlations
Entrez Gene 4782
Kegg hsa:4782
References
UniProt :accession P08651