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nuclear factor 1 B-type; NF1-B; nuclear factor 1/B; CCAAT-box-binding transcription factor; CTF; nuclear factor I/B; NF-I/B; NFI-B; TGGCA-binding protein (NFIB)
Function:
- recognizes & binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral & cellular promoters & in the origin of replication of adenovirus type 2
- these proteins are individually capable of activating transcription & replication
- binds DNA as a homodimer
Structure:
- belongs to the CTF/NF-I family
- contains 1 CTF/NF-I DNA-binding domain
Compartment: nucleus
Alternative splicing:
- named isoforms=3
- additional isoforms seem to exist
General
nuclear factor 1; CCAAT box-binding transcription factor; CTF; TGGCA-binding protein
phosphoprotein
Properties
SIZE: entity length = 420 aa
MW = 47 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 1-195
MOTIF: Ser phosphorylation site {S63}
Ser phosphorylation site {S264}
Ser phosphorylation site {S265}
Ser phosphorylation site {S292}
Ser phosphorylation site {S295}
Ser phosphorylation site {S328}
Ser phosphorylation site {S332}
Database Correlations
OMIM 600728
UniProt O00712
PFAM correlations
Entrez Gene 4781
Kegg hsa:4781
References
UniProt :accession O00712