Search
nuclear factor 1 A-type; NF1-A; nuclear factor 1/A; CCAAT-box-binding transcription factor; CTF; nuclear factor I/A; NF-I/A; NFI-A; TGGCA-binding protein (NFIA, KIAA1439)
Function:
- recognizes & binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral & cellular promoters & in the origin of replication of adenovirus type 2
- these proteins are individually capable of activating transcription & replication
- binds DNA as a homodimer
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the CTF/NF-I family
- contains 1 CTF/NF-I DNA-binding domain
Compartment: nucleus
General
nuclear factor 1; CCAAT box-binding transcription factor; CTF; TGGCA-binding protein
phosphoprotein
Properties
SIZE: entity length = 509 aa
MW = 56 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 1-194
Ser phosphorylation site {S258}
Ser phosphorylation site {S265}
Ser phosphorylation site {S280}
Ser phosphorylation site {S287}
Ser phosphorylation site {S300}
Ser phosphorylation site {S305}
Ser phosphorylation site {S319}
Database Correlations
OMIM 600727
UniProt Q12857
PFAM correlations
Entrez Gene 4774
Kegg hsa:4774
References
UniProt :accession Q12857