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nuclear factor erythroid 2-related factor 3; NF-E2-related factor 3; NFE2-related factor 3; nuclear factor, erythroid derived 2, like 3 (NFE2L3, NRF3)
Function:
- activates erythroid-specific, globin gene expression
- heterodimer with MAFG, MAFK & other small MAF proteins that bind to MAF recognition elements (MARE)
Compartment: nucleus
Expression:
- highly expressed in human placenta, B-cell & monocyte cell lines
- low expression in heart, brain, lung, skeletal muscle, kidney, pancreas
General
DNA-binding protein
Properties
SIZE: entity length = 694 aa
MW = 76 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 583-598
leucine zipper
SITE: 606-628
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 604135
UniProt Q9Y4A8
Pfam PF00170
Entrez Gene 9603
Kegg hsa:9603
References
OMIM :accession 604135