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nuclear factor erythroid 2-related factor 1; NF-E2-related factor 1; NFE2-related factor 1; locus control region-factor 1; nuclear factor, erythroid derived 2, like 1; transcription factor 11; TCF-11; transcription factor HBZ17; transcription factor LCR-F1 (NFE2L1, HBZ17, NRF1, TCF11)
Function:
- activates erythroid-specific, globin gene expression
Structure:
- belongs to the bZIP family, CNC subfamily
- contains 1 bZIP domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
General
DNA-binding protein
phosphoprotein
Properties
SIZE: entity length = 772 aa
MW = 85 kD
COMPARTMENT: cell nucleus
MOTIF: acidic region {125-288}
MOTIF: acidic residue (SEVERAL)
serine-rich region {496-517}
MOTIF: serine residue (SEVERAL)
Tyr phosphorylation site {Y645}
DNA-binding motif
SITE: 659-674
leucine zipper
SITE: 682-704
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM 163260
UniProt Q14494
Pfam PF00170
Entrez Gene 4779
Kegg hsa:4779
References
- UniProt :accession Q14494