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nuclear factor 1 X-type (nuclear factor 1/X, NF1-X, NFI-X, NF-I/X, CCAAT-box-binding transcription factor, CTF, TGGCA-binding protein, NFIX)
Function:
1) recognizes & binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral & cellular promoters
2) capable of activating transcriptio
3) binds DNA as homodimer
Structure:
- contains 1 CTF/NF-I DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=5
Pathology:
1) binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral promoters & in the origin of replication of adenovirus type 2
2) capable of activating transcription & replication
General
nuclear factor 1; CCAAT box-binding transcription factor; CTF; TGGCA-binding protein
Properties
SIZE: MW = 55 kD
entity length = 502 aa
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 1-194
Database Correlations
OMIM 164005
UniProt Q14938
PFAM correlations
References
UniProt :accession Q14938