nuclear envelope pore membrane protein POM 121C; pore membrane protein of 121 kD; nuclear pore membrane protein 121-2; POM121-2 (POM121C)

Function: - essential component of the nuclear pore complex (NPC) - the repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane - when overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) Structure: - contains F-X-F-G repeats - belongs to the POM121 family Compartment: - nucleus, nuclear pore complex, nucleus membrane - endoplasmic reticulum membrane - stably associated with the nuclear pore complex throughout interphase & the endoplasmic reticulum during metaphase (putative)

General

membrane protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 1229 aa MW = 125 kD COMPARTMENT: cell nucleus endoplasmic reticulum MOTIF: nuclear targeting {1-398} MOTIF: Cisternal side {1-40} transmembrane domain {41-61} Pore side {62-1229} MOTIF: proline-rich region SITE: 131-191 MOTIF: proline residue (SEVERAL) serine-rich region {322-444} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S322} Ser phosphorylation site {S323} Ser phosphorylation site {S325} Ser phosphorylation site {S328} Ser phosphorylation site {S366} Ser phosphorylation site {S368} Ser phosphorylation site {S369} Ser phosphorylation site {S370} Ser phosphorylation site {S373} Ser phosphorylation site {S412} threonine-rich region {728-924} MOTIF: threonine residue (SEVERAL)

References

UniProt :accession A8CG34