nuclear body protein SP140 (nuclear autoantigen Sp-140, speckled 140 kD, LYSp100 protein, lymphoid-restricted homolog of Sp100, SP140, LYSP100)

Function: 1) component of the nuclear body 2) induced by interferons Structure: - contains 1 bromo domain - contains 1 PHD-type zinc finger - contains 1 SAND domain Compartment: - nucleus, cytoplasm - localized to nuclear structures termed LANDS Alternative splicing: named isoforms=3 Expression: - expressed in spleen & peripheral blood leukocytes > thymus, prostate, ovary, small intestine, colon > heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas Pathology: 1) role in pathogenesis of acute promyelocytic leukemia & viral infection 2) antigen is recognized by autoantibodies from patients with primary biliary cirrhosis

General

nuclear protein zinc finger protein

Properties

SIZE: MW = 100 kD entity length = 882 aa COMPARTMENT: cytoplasm nuclear membrane MOTIF: nuclear translocation signal {495-514} SAND {580-661} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 690-736 EFFECTOR-BOUND: Zn+2 bromodomain {796-829}

Database Correlations

OMIM 608602 UniProt Q13342 PFAM correlations

References

UniProt :accession Q13342