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NPM (nucleophsomin) gene
5q35
Expression:
- NPM expression is cell cycle regulated & reaches peak levels before entry into S phase & decline to baseline before onset of G2 phase
Pathology:
- chromosomal translocation t3q25:5q34 leads to the NPM-MLF1 fusion protein, responsible for myelodysplastic syndrome with progression to acute myeloid leukemia (AML)
Related
chromosomal translocation t(3;5)(q25.1;q34)
NPM1 gene mutation
nucleophosmin; NPM; nucleolar phosphoprotein B23; numatrin; nucleolar protein NO38; nucleoplasmin 1 (NPM1, NPM)
General
unclassified gene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: nucleophosmin
LOCUS: human chromosome-5 Q35
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM 164040
Entrez Gene 4869