NPLOC4-UFD1L-VCP complex

Function: - binds ubiquitinated proteins - role in export of misfolded proteins from ER to cytoplasm, where they are degraded by the proteasome - regulates spindle disassembly at the end of mitosis - role in formation of a closed nuclear envelope - ubiquitin fusion protein degradation (UFD) pathway Structure: - consists of: ternary complex containing UFD1L, VCP & NPLOC4

Properties

COMPARTMENT: cell nucleus SUBUNITS: nuclear protein localization protein 4 homolog COMPARTMENT: cytoplasm cell nucleus endoplasmic reticulum MOTIF: Zinc finger NAME: Zinc finger SITE: 579-607 EFFECTOR-BOUND: Zn+2 ubiquitin fusion degradation protein 1 homolog COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S245} Ser phosphorylation site {S247} Ser phosphorylation site {S299} valosin-containing protein COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S7} ATP-binding site NAME: ATP-binding site SITE: 245-252 ATP-binding site NAME: ATP-binding site SITE: 518-525 Ser phosphorylation site {S702} Ser phosphorylation site {S705} Ser phosphorylation site {S784} Tyr phosphorylation site {Y805}

References

UniProt :accession Q8IY57

Components

nuclear protein localization protein 4 homolog; protein NPL4 (NPLOC4, KIAA1499, NPL4) ubiquitin fusion degradation protein 1 homolog; UB fusion protein 1 (UFD1L) valosin-containing protein; transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg+2-ATPase p97 subunit (VCP)