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protein NOV homolog; NovH; nephroblastoma overexpressed gene protein homolog (NOV, CCN3, IGFBP9, NOVH)
Function:
- immediate-early protein
- role in cell growth regulation (putative)
- interacts with FBLN1
Structure:
- belongs to the CCN family
- contains 1 CTCK (C-terminal cystine knot-like) domain
- similarity to insulin like growth factor binding proteins
- contains 1 IGFBP N-terminal domain
- contains 1 TSP type-1 domain
- contains 1 VWFC domain
Compartment: secreted
Pathology:
- increased expression in
a) Wilms tumor of the stromal type
b) avian nephroblastoma
General
glycoprotein
growth factor
proto oncogene protein
secreted protein
Properties
SIZE: entity length = 357 aa
MW = 39 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-31}
IGFBP N-terminal {32-105}
MOTIF: N-glycosylation site {N97}
VWFC domain {108-174}
TSP type-1 {205-250}
C-terminal cystine knot {264-338}
MOTIF: cysteine residue {C264}
MODIFICATION: cysteine residue {C301}
N-glycosylation site {N280}
cysteine residue {C281}
MODIFICATION: cysteine residue {C315}
cysteine residue {C292}
MODIFICATION: cysteine residue {C331}
cysteine residue {C295}
MODIFICATION: cysteine residue {C333}
cysteine residue {C300}
MODIFICATION: cysteine residue {C337}
cysteine residue {C301}
MODIFICATION: cysteine residue {C264}
cysteine residue {C315}
MODIFICATION: cysteine residue {C281}
cysteine residue {C331}
MODIFICATION: cysteine residue {C292}
cysteine residue {C333}
MODIFICATION: cysteine residue {C295}
cysteine residue {C337}
MODIFICATION: cysteine residue {C300}
Database Correlations
OMIM 164958
UniProt P48745
PFAM correlations
Kegg hsa:4856
References
UniProt :accession P48745
Component-of
guaifenesin/nov protein/pseudoephedrine
glycerol/naphazoline/nov protein
dextromethorphan/guaifenesin/nov protein/pseudoephedrine
chlorcyclizine/nov protein/phenylephrine
aspirin/citrate/diphenhydramine/nov protein