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notch (Drosophila) homolog protein

Function: - involved in developmental regulation - presenilins are involved in Notch cleavage [2] - leaved to yield cytoplasmic fragment that binds to & activates members of the CSL family of transcription factors [3]

Interactions

molecular events

Specific

notch homolog 2 N-terminal-like protein (NOTCH2NL N2N) notch homolog 2 N-terminal-like protein B (NOTCH2NLB) notch homolog 2 N-terminal-like protein C (NOTCH2NLC) notch homolog 2 N-terminal-like protein R; NOTCH2NL-related (NOTCH2NLR) notch-1 (Drosophila) homolog protein; translocation-associated notch homolog (NOTCH1, TAN1) notch-2 (Drosophila) homolog protein (NOTCH2) notch-3 (Drosophila) homolog protein (NOTCH3) notch-4 (Drosophila) homolog protein (NOTCH4, INT3)

General

cell surface receptor proto oncogene protein

Properties

COMPARTMENT: plasma membrane MOTIF: ligand-binding site EGF domain Notch/Lin12 repeat ankyrin repeat NAME: ankyrin repeat transmembrane domain

Database Correlations

Kegg hsa/hsa04330

References

  1. OMIM :accession [190198 600275 600276]
  2. Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 6;414(6864):643-8. PMID: 11740561
  3. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: 11274343

Component-of

molecular complex