notch homolog 2 N-terminal-like protein (NOTCH2NL N2N)

Function: - may function in the notch signaling pathway & regulate neutrophil differentiation - interacts with ELA2 - cleaved by ELA2 Structure: - belongs to the NOTCH family - contains 6 EGF-like domains Compartment: secreted, cytoplasm Alternative splicing: named isoforms=3 Expression: - widely expressed - higher levels in leukocytes & lymph nodes

General

glycoprotein notch (Drosophila) homolog protein secreted protein

Properties

SIZE: entity length = 236 aa MW = 26 kD COMPARTMENT: cytoplasm MOTIF: EGF domain {1-24} MOTIF: N-glycosylation site {N7} cysteine residue {C14} MODIFICATION: cysteine residue {C23} cysteine residue {C23} MODIFICATION: cysteine residue {C14} EGF domain {25-63} MOTIF: cysteine residue {C29} MODIFICATION: cysteine residue {C40} cysteine residue {C34} MODIFICATION: cysteine residue {C51} cysteine residue {C40} MODIFICATION: cysteine residue {C29} cysteine residue {C51} MODIFICATION: cysteine residue {C34} cysteine residue {C53} MODIFICATION: cysteine residue {C62} cysteine residue {C62} MODIFICATION: cysteine residue {C53} EGF domain {66-104} MOTIF: cysteine residue {C70} MODIFICATION: cysteine residue {C82} cysteine residue {C76} MODIFICATION: cysteine residue {C92} cysteine residue {C82} MODIFICATION: cysteine residue {C70} cysteine residue {C92} MODIFICATION: cysteine residue {C76} cysteine residue {C94} MODIFICATION: cysteine residue {C103} cysteine residue {C103} MODIFICATION: cysteine residue {C94} EGF domain {105-141} MOTIF: cysteine residue {C109} MODIFICATION: cysteine residue {C120} cysteine residue {C114} MODIFICATION: cysteine residue {C129} cysteine residue {C120} MODIFICATION: cysteine residue {C109} cysteine residue {C129} MODIFICATION: cysteine residue {C114} cysteine residue {C131} MODIFICATION: cysteine residue {C140} cysteine residue {C140} MODIFICATION: cysteine residue {C131} EGF domain {143-180} MOTIF: cysteine residue {C147} MODIFICATION: cysteine residue {C159} cysteine residue {C153} MODIFICATION: cysteine residue {C168} cysteine residue {C159} MODIFICATION: cysteine residue {C147} cysteine residue {C168} MODIFICATION: cysteine residue {C153} cysteine residue {C170} MODIFICATION: cysteine residue {C179} cysteine residue {C179} MODIFICATION: cysteine residue {C170} EGF domain {182-219} MOTIF: cysteine residue {C186} MODIFICATION: cysteine residue {C197} cysteine residue {C191} MODIFICATION: cysteine residue {C207} cysteine residue {C197} MODIFICATION: cysteine residue {C186} cysteine residue {C207} MODIFICATION: cysteine residue {C191}

Database Correlations

UniProt Q7Z3S9 PFAM correlations Kegg hsa:3886

References

UniProt :accession Q7Z3S9