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Notch extracellular truncation (NEXT)
NEXT is the product of 2 proteolytic cleavages of NOTCH1, 1st by furin at S1, then by ADAM17 at S2. NEXT is the substrate of gamma-secretase. NEXT cleavage occurs between gly1743 & val1744 of parent Notch-1 (S3). Cleavage serves to release the NOTCH1 intracellular domain (NICD) from the membrane. NICD then translocates to the nucleus, where it functions as a transcriptional activator in concert with CSL family members.
Interactions
molecular events
Related
notch-1 (Drosophila) homolog protein; translocation-associated notch homolog (NOTCH1, TAN1)
General
peptide
References
- De Strooper B, Annaert W.
Where Notch and Wnt signaling meet. The presenilin hub.
J Cell Biol. 2001 Feb 19;152(4):F17-20.
PMID: 11266476