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norethindrone (Norlutate, Aygestin, Micronor)
Tradenames: Norlutate, Aygestin, Micronor Progestin.
Indications:
- amenorrhea or abnormal uterine bleeding due to hormonal imbalance
- endometriosis
- oral contraceptive (alone or in combination with estrogens)
Dosage: 5-10 mg PO QD PRN.
Tablets: (acetate, Norlutate) 5 mg. Oral Contraceptives:
- 0.35 mg QD for 28 days of cycle (28 days)
Tablets: (Micronor) 0.35 mg
Tablets: (acetate, Norlutate) 5 mg.
Adverse effects:
1) common (> 10%)
- breakthrough bleeding, spotting, changes in menstrual flow, amenorrhea, pain at site of injection, anorexia, edema, weakness
2) less common (1-10%)
- edema, depression, fever, melasma, chloasma, allergic rash with or without pruritus, cholestatic jaundice,changes in cervical erosion & secretions, weight gain or loss, insomnia, breast tenderness
General
progestational agent
Properties
MISC-INFO: elimination route LIVER
pregnancy-category D
X
safety in lactation ?
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
Component-of
Activella
Combipatch
estradiol/ethinyl estradiol/ferrous fumarate/iron/norethindrone
estradiol/ethinyl estradiol/ferrous fumarate/norethindrone
estradiol/ethinyl estradiol/norethindrone
estradiol/norethindrone
estradiol/norethindrone/relugolix
ethinyl estradiol/norethindrone (Junel Fe)
ethinyl estradiol/norethindrone/ferrous fumarate (Larin Fe)
Femhrt (ethinyl estradiol, norethindrone)
Femlyv (ethinyl estradiol, norethindrone)
leuprolide/norethindrone
Loestrin 24 Fe
mestranol/norethindrone
Ovcon-35