Na+ dependent noradrenaline transporter; norepinephrine transporter; NET; solute carrier family 6 member 2 (SLC6A2, NAT1, NET1, SLC6A5)

Function: - amine transporter - terminates the action of noradrenaline by its high affinity Na⁺-dependent reuptake into presynaptic terminals - interacts with PRKCABP Structure: - belongs to the Na⁺:neurotransmitter symporter (SNF) family Compartment: membrane Expression: - a 5.8 kB mRNA transcript is localized to adrenal medulla & locus ceruleus norepinephrine neurons - a 3.6 kB mRNA transcript is ubiquitously expressed - may be cross hybridization or glial-specific form Pathology: - defects in SLC6A2 are a cause of orthostatic intolerance

General

adenosine triphosphatase (ATPase) glycoprotein solute carrier family 6 (neurotransmitter transporter, SLC6, SLC6A)

Properties

SIZE: entity length = 617 aa MW = 69 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-64} transmembrane domain {65-85} exoplasmic loop {86-92} transmembrane domain {93-112} cytoplasmic loop {113-135} transmembrane domain {136-156} exoplasmic loop {157-234} MOTIF: N-glycosylation site {N184} N-glycosylation site {N192} N-glycosylation site {N198} transmembrane domain {235-253} cytoplasmic loop {254-261} transmembrane domain {262-279} exoplasmic loop {280-314} transmembrane domain {315-332} cytoplasmic loop {333-343} transmembrane domain {344-365} exoplasmic loop {366-397} transmembrane domain {398-417} cytoplasmic loop {418-443} transmembrane domain {444-462} exoplasmic loop {463-477} transmembrane domain {478-498} cytoplasmic loop {499-518} transmembrane domain {519-538} exoplasmic loop {539-556} transmembrane domain {557-575} cytoplasmic domain {576-617} MISC-INFO: messenger RNA :SIZE entity length :VALUE 5.8 :UNITS KB Ki [desipramine] 3.88 NM

Database Correlations

OMIM correlations MORBIDMAP 163970 UniProt P23975 Pfam PF00209 Entrez Gene 6530 Kegg hsa:6530