ribosomal RNA methyltransferase NOP2; nucleolar protein 2 homolog; nucleolar protein 1; proliferating-cell nucleolar antigen p120; proliferation-associated nucleolar protein p120 (NOP2, NOL1)

Function: - may play a role in the regulation of the cell cycle & the increased nucleolar activity that is associated with cell proliferation - may act as ribosomal RNA methyltransferase - interaction with MCRS1 Structure: - belongs to the methyltransferase superfamily, RsmB/NOP family Compartment: nucleus, nucleolus Alternative splicing: named isoforms=2 Expression: - expressed in G1 phase - peaks during the early S phase of the cell cycle

General

methyltransferase nuclear protein phosphoprotein

Properties

SIZE: entity length = 812 aa MW = 89 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S36} Ser phosphorylation site {S58} Thr phosphorylation site {T64} Ser phosphorylation site {S67} Ser phosphorylation site {S111} Ser phosphorylation site {S120} Ser phosphorylation site {S134} Thr phosphorylation site {T140} Ser phosphorylation site {S150} Ser phosphorylation site {S181} Thr phosphorylation site {T185} Thr phosphorylation site {T195} S-adenosyl-L-methionine binding {392-398} binding site SITE: 416-416 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 443-443 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 460-460 FOR-BINDING-OF: S-adenosylmethionine cysteine residue {C517} Thr phosphorylation site {T603} Ser phosphorylation site {S666} Ser phosphorylation site {S675} Ser phosphorylation site {S732} Ser phosphorylation site {S734} Thr phosphorylation site {T739} Thr phosphorylation site {T776} Ser phosphorylation site {S786} Ser phosphorylation site {S812}

Database Correlations

OMIM 164031 UniProt P46087 PFAM correlations Entrez Gene 4839 Kegg hsa:4839