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reticulon-4 receptor; Nogo receptor; NgR; Nogo-66 receptor (RTN4R, NOGOR, UNQ330/PRO526)
Function:
- receptor for RTN4, OMG & MAG
- mediates axonal growth inhibition
- may play a role in regulating axonal regeneration & plasticity in the adult central nervous system
- interacts with LINGO1
Structure:
- homomultimer
- belongs to the Nogo receptor family
- contains 9 LRR repeats (leucine-rich repeats)
Compartment: cell membrane; lipid-anchor, GPI-anchor
Expression:
- widespread in the brain
- highest levels in gray matter
- low levels in heart & kidney
- not expressed in oligodendrocytes (white matter)
Interactions
molecular events
General
glypiated protein
receptor
Properties
SIZE: entity length = 473 aa
MW = 51 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-26}
cysteine residue {C27}
MODIFICATION: cysteine residue {C33}
cysteine residue {C31}
MODIFICATION: cysteine residue {C43}
cysteine residue {C33}
MODIFICATION: cysteine residue {C27}
cysteine residue {C43}
MODIFICATION: cysteine residue {C31}
leucine-rich repeat
SITE: 55-79
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 81-103
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N82}
leucine-rich repeat
SITE: 104-128
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 129-152
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 153-176
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 178-200
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N179}
leucine-rich repeat
SITE: 202-224
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 225-248
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 250-273
MOTIF: leucine residue (SEVERAL)
cysteine residue {C264}
MODIFICATION: cysteine residue {C287}
cysteine residue {C266}
MODIFICATION: cysteine residue {C309}
cysteine residue {C287}
MODIFICATION: cysteine residue {C264}
cysteine residue {C309}
MODIFICATION: cysteine residue {C266}
glycine-rich region {435-442}
glycosyl phosphatidylinositol [GPI] membrane anchor {N447}
Database Correlations
OMIM 605566
MORBIDMAP 605566
UniProt Q9BZR6
Pfam PF00560
Entrez Gene 65078
Kegg hsa:6507
References
- UniProt :accession Q9BZR6
- Protein Spotlight; Note: nerve regrowth: nipped by a no-go
- Issue 69 of April 2006
http://www.expasy.org/spotlight/back_issues/sptlt069.shtml
- Fournier AE et al
Identification of a receptor mediating Nogo-66 inhibition of
axonal regeneration.
Nature 409:341-346, 2001
PMID: 11201742
- Liu BP et al
Myelin-associated glycoprotein as a functional ligand for the
Nogo-66 receptor
Science 297:1190-3, 2002
PMID: 12089450
Component-of
molecular complex