Nodal modulator 2 (pM5 protein 2, NOMO2)

Function: - may antagonize Nodal signaling & subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN - interacts with NCLN Compartment: endoplasmic reticulum membrane Alternative splicing: named isoforms=2 Expression: - expressed in pancreas & skeletal > heart Genetics: - there are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1, NOMO2 (AC Q5JPE7) & NOMO3 (AC P69849) - all 3 very similar

General

glycoprotein membrane protein

Properties

SIZE: MW = 139 kD entity length = 1267 aa COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-31} N-glycosylation site {N50} N-glycosylation site {N218} N-glycosylation site {N618} transmembrane domain {1156-1176}

Database Correlations

UniProt Q5JPE7 Pfam PF05738

References

UniProt :accession Q5JPE7