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nociceptin receptor; orphanin FQ receptor; kappa-type 3 opioid receptor; KOR-3 (OPRL1 OOR ORL1)
Function:
- receptor for the neuropeptide nociceptin/orphanin FQ
- potential role in modulating a number of brain functions, including instinctive behaviors & emotions
- activity is mediated by Gi protein (inhibition of adenylyl cyclase)
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Alternative splicing: named isoforms=2
Expression: induced by phytohemagglutinin (PHA)
General
endorphin receptor or opioid receptor
glycoprotein
Properties
SIZE: entity length = 370 aa
MW = 41 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-50}
MOTIF: N-glycosylation site {N21}
N-glycosylation site {N28}
N-glycosylation site {N39}
transmembrane domain {51-77}
cytoplasmic loop {78-87}
transmembrane domain {88-109}
exoplasmic loop {110-124}
MOTIF: cysteine residue {C123}
MODIFICATION: cysteine residue {C200}
transmembrane domain {125-146}
cytoplasmic loop {147-165}
transmembrane domain {166-188}
exoplasmic loop {189-211}
MOTIF: cysteine residue {C200}
MODIFICATION: cysteine residue {C123}
transmembrane domain {212-236}
cytoplasmic loop {237-264}
transmembrane domain {265-288}
exoplasmic loop {289-300}
transmembrane domain {301-322}
cytoplasmic domain {323-370}
MOTIF: cysteine residue {C334}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 602548
UniProt P41146
Pfam PF00001
Kegg hsa:4987
References
UniProt :accession P41146