NMDA receptor-regulated protein 1; N-alpha-acetyltransferase 15, natA auxiliary subunit; gastric cancer antigen Ga19; N-terminal acetyltransferase; protein tubedown-1; Tbdn100 (NAA15, GA19, NARG1, NATH, TBDN100)

Function: 1) ARD1-NARG1 complex with acetyltransferase activity 2) vascular, hematopoietic & neuronal growth & development 3) retinal neovascularisation in adult ocular endothelial cells 4) in complex with XRCC6 (G22P1) & XRCC5 (Ku80), up-regulates transcription from osteocalcin promoter 5) interacts with XRCC6 (G22P1), XRCC5, ARD1 6) cleaved by caspases during apoptosis; results in stable 35 kD fragment Structure: contains 8 TPR repeats Compartment: cytoplasmic, nuclear in some cases Alternative splicing: named isoforms=2 Expression: - expressed at high levels in testis & ocular endothelial cells, brain (corpus callosum), heart, colon, bone marrow - lower levels in most adult tissues Pathology: - overexpressed in: a) gastric cancer b) papillary thyroid carcinoma c) Burkitt lymphoma cell line (Daudi cells). - specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy

General

nuclear protein phosphoprotein protein subunit

Properties

SIZE: entity length = 866 aa MW = 101 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: tetratricopeptide repeat {46-79} tetratricopeptide repeat {80-113} tetratricopeptide repeat {148-184} tetratricopeptide repeat {224-257} tetratricopeptide repeat {374-407} tetratricopeptide repeat {409-441} tetratricopeptide repeat {485-518} nuclear translocation signal {612-629} tetratricopeptide repeat {672-705} Thr phosphorylation site {T850} Ser phosphorylation site {S855} Ser phosphorylation site {S856}

Database Correlations

OMIM 608000 UniProt Q9BXJ9 PFAM correlations Entrez Gene 80155 Kegg hsa:80155

References

OMIM :accession Q9BXJ9