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granulysin; lymphokine LAG-2; protein NKG5; T-cell activation protein 519 (GNLY, LAG2, NKG5, TLA519)
Function:
- antimicrobial protein that kills intracellular pathogens
- active against a broad range of microbes, including Gram-positive bacteria & Gram-negative bacteria, fungi, & parasites
- kills Mycobacterium tuberculosis
- a 9 kD form is produced by proteolytic processing of a 15 kD protein
Structure: contains 1 saposin B-type domain
Compartment:
- secreted
- located in the cytotoxic granules of T-cells, which are released upon antigen stimulation
Alternative splicing: named isoforms=2
Expression:
- expressed in natural killer & T-cells
- induced by T-cell growth factor & IL2
General
secreted protein
Properties
SIZE: entity length = 145 aa
MW = 16 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
Saposin B-type {62-142}
MOTIF: cysteine residue {C69}
MODIFICATION: cysteine residue {C132}
cysteine residue {C96}
MODIFICATION: cysteine residue {C107}
cysteine residue {C107}
MODIFICATION: cysteine residue {C96}
cysteine residue {C132}
MODIFICATION: cysteine residue {C69}
Database Correlations
OMIM 188855
UniProt P22749
Pfam PF03489
Entrez Gene 10578
Kegg hsa:10578
References
UniProt :accession P22749