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NKG2-E type II integral membrane protein; NKG2-E-activating NK receptor; NK cell receptor E; killer cell lectin-like receptor C3 (KLRC3, NKG2E)
Function:
- plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells & some cytotoxic T-cells
- can form disulfide-bonded heterodimer with CD94
Structure: contains 1 C-type lectin domain
Compartment: membrane
Alternative splicing: named isoforms=2; NKG2-E, NKG2-H
Expression: natural killer cells
General
glycoprotein
killer cell lectin-like receptor C subfamily or NKG2 receptor
Properties
SIZE: entity length = 240 aa
MW = 27 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {71-93}
N-glycosylation site {N100}
C-type lectin {116-230}
MOTIF: cysteine residue {C117}
MODIFICATION: cysteine residue {C128}
cysteine residue {C128}
MODIFICATION: cysteine residue {C117}
N-glycosylation site {N149}
N-glycosylation site {N179}
cysteine residue {C207}
MODIFICATION: cysteine residue {C220}
cysteine residue {C220}
MODIFICATION: cysteine residue {C207}
Database Correlations
OMIM 602892
UniProt Q07444
Pfam PF00059
Entrez Gene 3823
Kegg hsa:3823
References
- UniProt :accession Q07444
- Functional Glycomics gateway - Glycan binding; Note: NKG-2E
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_247