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CD314; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NK cell receptor D; killer cell lectin-like receptor subfamily K member 1 (KLRK1, D12S2489E, NKG2D)
Function:
- receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) & ULBP4
- plays a role as a receptor forrecognition of MHC class I HLA-E molecules by NK cells & some cytotoxic T-cells
- involved in the immune surveillance exerted by T-cells & B-cells
- interacts with DAP10
- interaction with DAP10 is required for NKG2D cell surface expression
Structure:
- homodimer
- contains 1 C-type lectin domain
Compartment: membrane
Alternative splicing: named isoforms=1
A number of isoforms are produced
Expression:
- natural killer cells
- expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC
- also detected in gamma-delta cells & CD8+ alpha-beta T-cells
- expressed in interferon-producing killer dendritic cells
Note:
- structurally distinct families of ligands for mouse & human NKG2D receptors have been characterized; they might be orthologs
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
killer cell lectin-like receptor C subfamily or NKG2 receptor
Properties
SIZE: entity length = 216 aa
MW = 25 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {52-72}
cysteine residue {C96}
MODIFICATION: cysteine residue {C105}
C-type lectin {98-213}
MOTIF: cysteine residue {C99}
MODIFICATION: cysteine residue {C110}
cysteine residue {C105}
MODIFICATION: cysteine residue {C96}
cysteine residue {C110}
MODIFICATION: cysteine residue {C99}
cysteine residue {C127}
MODIFICATION: cysteine residue {C211}
N-glycosylation site {N131}
N-glycosylation site {N163}
cysteine residue {C189}
MODIFICATION: cysteine residue {C203}
N-glycosylation site {N202}
cysteine residue {C203}
MODIFICATION: cysteine residue {C189}
cysteine residue {C211}
MODIFICATION: cysteine residue {C127}
Database Correlations
OMIM 611817
UniProt P26718
Pfam PF00059
Entrez Gene 8302
References
- UniProt :accession P26718
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/KLRK1ID41094ch12p13.html
- Functional Glycomics gateway - Glycan binding; Note: NKG-2D
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_246